Tapentadol is a benzenoid opioid analgesic sold under the brand names Nucynta and others. It works in two ways: as an agonist of the -opioid receptor and as a norepinephrine reuptake inhibitor. After oral treatment, analgesia begins in 32 minutes and lasts 4–6 hours. Tapentadol extended-release (Nucynta ER) is used to treat pain that is not controlled by other drugs. Tapentadol...