How does buprenorphine treat opioid abuse?

Buprenorphine activates the same opioid receptors in the body as opioids, but it binds to the receptor in a slightly different manner. Due to the activation of these receptors, buprenorphine effectively alleviates withdrawal symptoms (which result when these receptors are not activated) but is less likely to produce an overdose.

Buprenorphine must be administered only after all other opioids have been eliminated from the body; otherwise, it can cause sudden and severe withdrawal symptoms. When people with OUD begin to experience withdrawal symptoms, they will take their first dose of buprenorphine, which will rapidly provide relief.

The most frequently prescribed formulation of this medication is the sublingually dissolvable combination product buprenorphine/naloxone (Buy Subutex Online). This combination medication is preferred by providers to protect their patients from relapse or toxicity, which is reported to occur in over 70% of OUD patients. The naloxone component of the medication prevents buprenorphine from producing harmful adverse effects if it is abused.

What distinguishes methadone from buprenorphine?

Methadone binds to opioid receptors in the body, but it activates them similarly to conventional opioids. This implies that methadone can be administered prior to the elimination of other opioids from the body.

Methadone is the medication of choice for individuals with severe OUD because it is more effective and reduces cravings than buprenorphine.

Prescription methods are another significant distinction between methadone and buprenorphine. A prescriber in a typical office can submit an application to become an authorized buprenorphine provider, making it simpler to locate a provider. The prescriptions for buprenorphine can then be completed at a nearby pharmacy.

Considerable side effects

As with all medications, you should be aware of the risks and adverse effects of buprenorphine and methadone before beginning either.

Buprenorphine

Buprenorphine is known to induce liver damage, particularly in patients with a history or current liver disease. Regular blood tests are performed to monitor liver health while taking this medication.

The most common buprenorphine side effects include:

Headache

Trouble resting

Pain

Withdrawal symptoms

Nausea

Sweating

gastrointestinal discomfort Infections

Methadone

As with other opioid medications, methadone can induce respiratory depression and overdoses. A provider may request that a patient remain at the OTP for some time after a dose to prevent this, particularly when initiating methadone treatment. Since this adverse effect may also occur several hours after a dose, it is advised to obtain a naloxone (Narcan) emergency kit from a local pharmacy if the OTP does not provide one.

The most common methadone side effects include:

Lightheadedness

Dizziness

Sleepiness

Nausea

Vomiting

Sweating

Can one become addicted to methadone or Buprenorphine?

These medications are categorized as controlled substances, which means they pose a risk of physical dependence and addiction (buprenorphine poses a lower risk). However, both medications can be used safely to treat OUD if you meticulously adhere to your doctor's dosage and instructions.

For some individuals, the aim is to eventually stop taking these medications. Others may choose to maintain a lower dose over time. Your dosage and duration of administration are unique to you. Be open and honest with your provider about your objectives, so they can do their best to assist you in achieving them.

Conclusion

Both methadone and buprenorphine are effective medications for treating OUD. There are several significant distinctions between them, but the most significant difference is how they are prescribed and distributed. Whether you are taking buprenorphine or methadone, you should be aware that both are considered first-line treatments for OUD and are known to save lives.

How to purchase Subutex and Methadone?

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