Wnt/Notch/Hedgehog Library Chemical Structure : GLPG-1690 CAS No.: 1628260-79-6 聽聽聽聽 GLPG-1690(Ziritaxestat;GLPG 1690;GLPG1690) Catalog No.:聽URK-V653聽Only Used For Lab. GLPG-1690 (Ziritaxestat, GLPG1690) is a first-in-class, potent, competitive autotaxin inhibitor with Ki/IC50 of 15 nM/131 nM. 聽 Biological Activity GLPG-1690 (Ziritaxestat, GLPG1690) is a first-in-class, potent, competitive autotaxin inhibitor with Ki/IC50 of 15 nM/131 nM; inhibits ATX-induced LPA 18:2 production in mouse, rat, and healthy donor plasma with IC50 of 418 nM, 542 nM, and 242 nM, respectively; shows no CYP3A4 TDI and decreased hERG inhibitory activity (IC50=15 uM), and good pharmacokinetic profile for treatment idiopathic pulmonary fibrosis. Fibrosis Phase 2 Clinical 聽 Physicochemical Properties M.Wt588.71 FormulaC30H33FN8O2S CAS No.1628260-79-6 StorageSolide Powder -20 掳C 3years; 4掳C 2yearsIn Solvent -80掳C 6 Months -20掳C 1 Months Solubility10 mM in DMSO Chemical Name2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]-piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]-methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile 聽 References 1. Desroy N, et al. J Med Chem. 2017 May 11;60(9):3580-3590. 聽 URK-V653_COA URK-V653_SDS URK-V653_TDS 聽 Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use! 聽Wnt/Notch/Hedgehog Library website:http://www.ureiko-chem.com/inhibitors-agonists/wnt-notch-hedgehog-library/
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